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X-CLARARY™是Logos Biosystems为了使电泳化组织清除简单、快速、高效而开发的系统和现成的试剂集合。
X-CLARITY™系统和试剂标准化、简化并加速了组织清理过程的每个步骤。通过CLARITY方法，保存的组织被嵌入到水凝胶基质中，脂质通过电泳被主动提取，从而创建一个稳定的、光学透明的组织-水凝胶混合物，可以在化学上进行多轮抗体标记和成像。天然的细胞结构保持完整，甚至内源性的荧光蛋白也被保存下来，用于下游的荧光成像。
X-CLARITY™水凝胶溶液套件是一种预先测试的水凝胶溶液，用于均匀和一致的组织-水凝胶杂交。试剂盒由X-CLARITY™水凝胶溶液(用于生成聚丙烯酰胺的丙烯酰胺基溶液)和X-CLARITY™聚合引发剂(热自由基引发剂，也称为VA-044)组成。
X-CLARITY™聚合系统是一个独立的、自动化的系统，用于简化组织-水凝胶杂交，这是优化组织清理的关键步骤。可将多个样本放置在多孔板或锥形管中，以实现快速高效的高通量样品处理。通过简单的触摸屏界面，用户可以通过调整真空强度、温度和计时器来控制聚合。
X-CLARITY™组织清除系统II是一个一体化，易于使用的电泳组织清除解决方案。其独特的设计加速清除组织中的脂质，同时保持样品的结构完整性。在短短6小时内清理整个小鼠的大脑，比原来的技术快了8倍。用户可以通过简单直观的触摸屏界面设置组织清除条件。在ETC(电泳组织清除)模式下，镀铂电极产生电场，以高效的方式加速清除组织中的脂质。内置的温度控制系统以保持一致的缓冲区温度，在清理过程中主动冷却和加热缓冲区。缓冲是不断循环，以确保一致的缓冲能力，温度控制，并消除组织清除的副产物。这种先进的系统确保高效，快速，一致的组织清除。
电泳组织清除液是一种预混的基于SDS的缓冲液，用于X-CLARITY™组织清理系统II。
For you if you want to accelerate your research!
Positive facts: X-CLARITY system is easy to use, devoted to aqueous-based method for organ clearing. It helps clearing several organs at once and in a short period of time. Works well on a lot of different mouse organs or even pieces of primates and humans organs. Logos Biosystems after Sales are fast and always find a compromise as a solution to our rare issues. Minus: expensive systems in comparison to passive clearing methods. For you if you want to accelerate your research!
INSERM UMR 1060
Great results, easy to use!
This product was effective at clearing my tissue samples. It cleared whole brains, hearts, stomach, kidneys, livers, etc. The user manual was easy to read and easy to follow. There is little attention and maintenance required while the system in running.
Clemson University
Influenza causes alterations to oligodendrocyte-specific transcripts and the myelin lipidome in the adult mouse central nervous system.
2021. Louie A, Kim J, Soto-Diaz K, Dibaeinia P, Koito H, Sinha S, Nowak R, Das A, Steelman A. Research Squre https://doi.org/10.21203/rs.3.rs-310861/v1.
Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models.
2021. Chourrout M, Rositi H, Ong E, Hubert V, Paccalet A, Foucault L, Autret A, Fayard B, Olivier C, Bolbos R, Peyrin F, Crola-da-Silva C, Meyronet D, Raineteau O, Elleaume H, Brun E, Chauveau F, Wiart M. bioRxiv 2021.03.24.436852.
Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels.
2021. Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F. Cardiovascular Research cvab126.
3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice.
2020. Ded L, Hwang JY, Miki K, Shi HF, Chung JJ. Elife 9:e62043.
Maximizing lentiviral vector gene transfer in the CNS.
2020. Humbel M, Ramosaj M, Zimmer V, Regio S, Aeby L, Moser S, Boizot A, Sipion M, Rey M, Déglon N. Gene Therapy 10.1038/s41434-020-0172-6.
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| Cat # | Product | Qty |
|---|---|---|
| C20001 | X-CLARITY™ Polymerization System | 1 unit |
| C20002 | X-CLARITY™ Heat Block for 6 x 50 mL tubes | 1 unit |
| C20003 | X-CLARITY™ Heat Block for flat-bottom plates | 1 unit |
| C1310X | X-CLARITY™ Hydrogel Solution Kit - X-CLARITY™ Hydrogel Solution (1 x 1 L) - X-CLARITY™ Polymerization Initiator (1 x 2.5 g) | 1 kit |
| C30001 | X-CLARITY™ Tissue Clearing System II | 1 unit |
| C12010 | Holder for 36 Mouse Brain Slices, 1.5 Φ | 1 set |
| C12020 | Holder for 36 Mouse Brain Slices, 0.6 Φ | 1 set |
| C12011 | Holder for 6 Slices, 1.5 Φ | 1 set |
| C12021 | Holder for 6 Slices, 0.6 Φ | 1 set |
| C12012 | Holder for 1 Sample, 1.5 Φ | 1 set |
| C12022 | Holder for 1 Sample, 0.6 Φ | 1 set |
| C12013 | Holder for 6 Mouse Brains, 1.5 Φ | 1 set |
| C12023 | Holder for 6 Mouse Brains, 0.6 Φ | 1 set |
| C12014 | Holder for 48 Samples, 1.5 Φ | 1 set |
| C12024 | Holder for 48 Samples, 0.6 Φ | 1 set |
| C12015 | Holder for 192 Samples, 1.5 Φ | 1 set |
| C12025 | Holder for 192 Samples, 0.6 Φ | 1 set |
| C12001 | Tissue Container (Whole Mouse Brain), 20 units | 1 box |
| C12002 | Container Holder for 1 Tissue Container | 1 unit |
| C12004 | Mouse Brain Slice Holder (Chamber Height: 4 mm) | 1 unit |
| C12007 | Whole Rat Brain Holder | 1 unit |
| C13001 | Electrophoretic Tissue Clearing Solution | 12 x 1 L |
| C13101 | X-CLARITY™ Mounting Solution | 1 x 25 mL |
| C13102 | X-CLARITY™ Mounting Solution Value Pack | 10 x 25 mL |
| C13107 | X-CLARITY™ Mounting Solution Bulk Pack | 20 x 25 mL |
| C33001 | DeepLabel™ Antibody Staining Kit - DeepLabel™ Solution A (1 x 25 mL) - DeepLabel™ Solution B (2 x 25 mL) - DeepLabel™ Washing Buffer (1 x 250 mL) | 1 kit |
| Display | 5” TFT LCD |
| Temperature Range | RT – 60 °C |
| Temperature Accuracy | ±0.3 °C |
| Vacuum Range | -90 – 0 kPa |
| Power Consumption | 312 W |
| Applicable Power | AC 100-240 V, 50/60 Hz |
| Dimensions (W x D x H) | Exterior: 332 x 430 x 222 mm Interior: 307 x 137 x 140 mm |
| Weight | 28 kg |
X-CLARITY™ ETC Chamber
| Instrument type | Electrophoretic chamber |
| External dimensions (W x D x H) | 176 mm x 128 mm x 154 mm |
| Internal dimensions (W x D x H) | 57 mm x 30 mm x 93 mm |
| Weight | 2.8 kg |
X-CLARITY™ ETC Control Tower
| Instrument type | Power supply, temperature control, and buffer circulation device |
| User interface | 5 “ TFT LCD touchscreen |
| Power supply modes | Constant current or constant voltage |
| Current & voltage range | 0.2-1.5 A, 5-70 V |
| Temperature range | 30-60 ° C |
| Pump speed range | 50-200 rpm |
| Electrical requirements | AC 100-240 V, 50/60 Hz |
| Power consumption | 500 W (including the X-CLARITY™ ETC Chamber) |
| Dimensions (W x D x H) | 205 mm x 430 mm x 370 mm |
| Weight | 20 kg |
